IRIS Toxicological Review of Hexavalent Chromium (Interagency Science Consultation Draft)

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On Septemeber 30, 2010, the draft Toxicological Review of Hexavalent Chromium and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Hexavalent Chromium and the charge to external peer reviewers are posted on this site.
Citation
U.S. EPA. IRIS Toxicological Review of Hexavalent Chromium (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/004C, 2010.
Status
Following external peer review the draft report will be revised taking into consideration external peer review and public comments, will undergo a final EPA internal review and a review by a science discussion with other federal agencies and White House offices, and then will finally be posted to the IRIS Web site.
The draft Toxicological Review of Hexavalent Chromium provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hexavalent chromium via ingestion.

Chromium is a naturally occuring element in the earth's crust. The three main forms of chromium found in the environment are chromium (0), chromium (III), and chromium (VI), also known as hexavalent chromium. Chromium is widely used in manufacturing processes, and it can be found in many consumer products such as wood treated with copper dichromate, leather tanned with chromic sulfate, and stainless steel cookware. Chromium is released to the environment from natural and anthropogenic sources, with the largest releases occurring from industrial sources. The general population may be exposed to chromium by inhaling ambient air, ingesting food, and drinking water containing chromium. Dermal exposure of the general public to chromium can occur from skin contact with certain consumer products or soils that contain chromium.
History/Chronology
Sep 1998The oral RfD for hexavalent chromium was posted to the IRIS database. The inhalation RfC for hexavalent chromium and the carcinogenicity assessment for hexavalent chromium were also posted to the IRIS database.
May 2010EPA initiated the interagency science consultation on the draft Toxicological Review of Hexavalent Chromium.
Sep 2010EPA released the external review draft for public review and comment. Additionally, EPA released the draft toxicological review and federal agency comments from the Interagency Science consultation.
Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.