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Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft)
Federal Register Notices
Contact
- Lynn Flowers
- by phone at: 703-347-8537
- by email at: flowers.lynn@epa.gov
Notice
EPA is announcing a 60-day public comment period and a public listening session for the external review draft document titled, Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft), as announced in the February 26, 2010 Federal Register Notice.
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) that when finalized will appear on the Integrated Risk Information System (IRIS) database. Please refer to IRISTrack - polycyclic aromatic hydrocarbon for the latest schedule updates.Downloads/Related Links
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures: In Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF) (622 pp, 7 MB, about PDF)
- Charge to External Reviewers (PDF) (5 pp, 80 KB, about PDF)
- SAB Polycyclic Aromatic Hydrocarbon (PAH) Mixtures Review Panel Web Site
Related Link(s)
- SAB Review of EPA's "Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (February 2010 Draft)" (PDF) (47 pp, 696 KB, about PDF)
- Draft (9/08/10) SAB Review of EPA's "Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures" (PDF) (40 pp, 512 KB, about PDF)
- Peer Consultation Workshop on Approaches to Polycyclic Aromatic Hydrocarbon (PAH) Health Assessment
Public Comments
Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2010-0047 (for the docket ID).
Background
PAHs are of concern as potential human health hazards, because many PAHs are demonstrated tumorigenic agents in animal bioassays and are positive in tests for genotoxicity or DNA damage. PAHs occur in the environment primarily as complex mixtures generated from the combustion of substances containing carbon and hydrogen, and rarely occur in the environment as isolated entities. The draft Relative Potency Factor approach is not a reassessment of individual PAH carcinogenicity, but rather provides a methodology for estimating cancer risk from exposure to PAH mixtures by summing doses of component PAHs after scaling the doses (with RPFs) relative to the potency of an index PAH (i.e., benzo[a]pyrene). The cancer risk is then estimated using the dose-response curve for the index PAH.
History/Chronology
Next Steps
Following External Peer Review and Public Comment, the final assessment is scheduled to be posted to the IRIS Web site.
Citation
U.S. EPA. Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/012A, 2010.