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IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (External Review Draft)

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Jeffrey S. Gift
by phone at:   919-541-4828
by fax at:   919-541-0245
by email at:  gift.jeff@epa.gov
EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene glycol monobutyl ether that will appear on the Integrated Risk Information System (IRIS) database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Related Link(s)

Public Comments

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2008-0245 docket ID).

The draft Toxicological Review of EGBE provides scientific information on the effects pertaining to exposure to EGBE. EGBE was nominated for reassesement by OAQPS in response to a delisting petition filed by the ACC. Ethylene glycol monobutyl ether (also known as 2-butoxyethanol) is a colorless liquid with an ether-like odor. It is widely used as a solvent in various applications such as in surface coatings, spray lacquer, quick-dry lacquers, enamels, varnishes, varnish removers, latex paint, and metal cleaners and in commercially available cleaning products. The chemical is released to the environment primarily through the use of commercial and household cleaning products. EGBE is a high production volume chemical with an estimated 390 million pounds produced in the United States in 1992 (NTP, 2000). Human exposure to ethylene glycol monobutyl ether (EGBE) is predominantly occupational via inhalation and dermal contact. Individuals employed in the manufacture, processing, and handling of EGBE will have potentially higher exposures (ATSDR, 1998). The primary routes of EGBE exposure to the general population are inhalation of contaminated indoor air and dermal contact with household products containing EGBE. The assessment will present reference values for the noncancer effects of EGBE (RfD and RfC), where supported by available data, and a cancer assessment.


Oct 1999EPA posted the first Toxicological Review for Ethylene Glycol mono-Butyl Ether (EGBE) on the IRIS database.
2002EGBE is nominated for reassessment by OAQPS in response to a delisting petition filed by the ACC.
Apr 2008EPA releases the reassessment of EGBE for public comment.
Sep 2008EPA announces the details for the external peer review meeting.
Oct 2008EPA announces a public listening session.
Oct 2009EPA releases the comments from the first and second rounds of this review were consolidated and reports are now available.
Nov 2009EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Ethylene Glycol Mono-Butyl Ether.
Mar 2010EPA releases the final report and the interagency review draft with comments.

Next Steps

Concluding this review, it is expected that there will be a final risk assessment in 2008 that will be published on the IRIS website.


U.S. EPA. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/006A.

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