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IRIS Toxicological Review of 2-Hexanone (External Review Draft)
Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.
Federal Register Notices
Contact
- Amanda Persad
- by phone at: 919-541-9781
- by fax at: 919-541-2985
- by email at: persad.amanda@epa.gov
- by fax at: 919-541-2985
Downloads/Related Links
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of 2-Hexanone: in Support of the Integrated Risk Information System (IRIS) (PDF) (118 pp, 687 KB, about PDF)
- Charge to External Peer Reviewers (PDF) (3 pp, 20 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (50 pp, 235 KB, about PDF)
Related Link(s)
- Final Report of Letter Peer Review of Key Study (PDF) (13 pp, 69 KB, about PDF)
Public Comments
Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2008-0048 (for the docket ID).
Background
2-Hexanone was nominated for IRIS assessment because of its frequent detection at sites nationwide and its occurrence as a byproduct of certain industrial processes. 2-Hexanone has been used as a solvent for lacquers, ink thinners, nitrocellulose, resins, oils, fats and waxes. The only U.S. producer of 2-hexanone, the Tennessee Eastman Company division of Eastman Kodak, discontinued its production of 2-hexanone in 1979 and sold its remaining reserves by 1981.
History/Chronology
| Jan 2008 | EPA completes the Interagency Review of the 2-hexanone Toxicological Risk Assessment. |
| Feb 2008 | EPA releases the first assessment of 2-hexanone in the IRIS database for public comment and review in preparation for an External Peer Review. |
| Mar 2008 | EPA released the external review draft for the Toxicological Review of 2-Hexane. |
| May 2008 | An external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 2-Hexanone (External Review Draft). |
| Sep 2009 | EPA released the Final Toxicological Review (PDF) (136 pp, 964K) and accompanying Summary for 2-Hexanone to the IRIS Web site. |
Next Steps
Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.
Citation
U.S. EPA. IRIS Toxicological Review of 2-Hexanone (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-2764, 2008.