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IRIS Agenda and Literature Searches

Contact
Gina Perovich
by phone at:   703-347-8656
by email at:  perovich.gina@epa.gov
IRIS is an EPA database of human health effects that may result from exposure to chemical substances found in the environment. EPA's process for developing IRIS assessments is described in detail on the IRIS Process Web page.

IRIS Literature Searches

[UPDATE] In March 2014, EPA announced the availability of 2 new literature searches along with additional preliminary materials (including the search strategy, evidence tables, and exposure-response figures) that forms the initial steps towards the development of the draft assessments for both diethyl phthalate (DEP) and hexabromocyclododecane (HBCD). That announcement came with a special message from the IRIS Program (PDF) (2pp, 70Kb) about enhancements to the bimonthly public meetings. These chemicals are on the agenda for discussion at the next IRIS bimonthly public meeting. [See Federal Register Notice Aug 9, 2013 for additional information about this announcement]

Since December 2007, EPA has actively solicited information from the public at the beginning of assessment development. As literature searches are completed, the results are posted here. All available literature searches are listed in the table below. The public is invited to review the literature search results and submit additional information to EPA through the regulations.gov web site. Instructions for submitting information are given below. Then, based on the results of the literature searches and as EPA resources allow, assessments will be started for those chemicals with data that may support development of one or more toxicity values. For a list of chemical currently under development, see IRISTrack.

Substance Literature Search Reports
(Click PDF Links)
# Pages Released
Acetaldehyde (CAS No. 75-07-0)
Document Attached
31
4/12
Acrylonitrile (CAS No. 107-13-1)
Document Attached
69
6/12
Carbonyl Sulfide (CAS No. 463-58-1)
Document Attached
113
12/07
Cobalt and Inorganic Cobalt Compounds
(CAS No. 7440-48-4 and various)
Document Attached
38
3/11
Cyclohexane* (CAS No. 110-82-7)
Document Attached
22
11/09
Diethyl Phthalate (DEP) (CAS No. 84-66-2)
Document Attached - 2014
Document Attached - 2007
129
30
3/14
12/07
Diisobutyl Phthalate (DIBP) (CAS No. 84-69-5)
Document Attached
7
5/10
Diisononyl Phthalate (DINP) (CAS No. 28553-12-0, 68515-48-0, 71549-78-5 and 14103-61-8)
Document Attached
8
5/10
Diisopropyl Ether (CAS No. 108-20-3)
Document Attached
8
12/07
Dipentyl Phthalate (DPP) (CAS No. 131-18-0)
Document Attached
7
5/10
Ethyl Tert-Butyl Ether (ETBE) (CAS No. 637-92-3)
Document Attached
58
8/13
n-Heptane* (CAS No. 142-82-5)
Document Attached
15
11/09
Hexabromocyclododecane
(CAS No. 3194-55-6, 25637-99-5, and 25495-98-1)
Document Attached - 2014
Document Attached - 2007
84
17
3/14
12/07
Hexachlorobutadiene (CAS No. 87-68-3)
Document Attached
24
12/10
Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)
(CAS No. 121-82-4)
Document Attached
93
8/13
Manganese (CAS No. 7439-9)
Document Attached
373
4/08
2-Methylbutane* (CAS No. 78-78-4)
Document Attached
4
11/09
Methylcyclohexane* (CAS No. 108-87-2)
Document Attached
10
11/09
2-Methylpentane* (CAS No. 107-83-5)
Document Attached
6
11/09
3-Methylpentane* (CAS No. 96-14-0)
Document Attached
6
11/09
N-Butanol (CAS No. 71-36-3)
Document Attached
12
12/07
N-Octane* (CAS No. 111-65-9)
Document Attached
12
11/09
Naphthalene (CAS No. 91-20-3)
Document Attached
34
12/10
Polychlorinated Biphenyls (noncancer) (various)
Document Attached
383
5/10
Tertiary Amyl Methyl Ether (CAS No. 994-05-8)
Document Attached
21
12/07
Tertiary-Butanol (CAS No. 75-65-0)
Document Attached
61
8/13
Toxaphene (CAS No. 8001-35-2)
Document Attached
102
12/07
2,2,5-Trimethylhexane* (CAS No. 3522-94-9)
Document Attached
4
11/09
2,3,3-Trimethylpentane* (CAS No. 560-21-4)
Document Attached
4
11/09
2,3,4-Trimethylpentane* (CAS No. 565-75-3)
Document Attached
5
11/09
Tungsten and related compounds (CAS No. 7440-33-7)
(Tungsten, Sodium Tungstate and
Tungsten Trioxide)
18
7
2
12/07
Vinyl Acetate (CAS No. 108-05-4)
Document Attached
23
3/11
Note* These chemicals are listed collectively in the IRIS agenda as alkylates.

The public is also invited to submit information for any chemical currently undergoing peer review and public comment (IRIS External Review Drafts).

IRIS Agenda

[UPDATE] In May, 2012, EPA is announced the 2012 IRIS agenda in the Federal Register and is requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including any assessments that EPA has started this year. [Federal Register Notice May 7, 2012]

See the history section (below) for a list of IRIS Agenda's previously announced in the Federal Register.


Background

History/Chronology

May 2012EPA is announced the 2012 IRIS agenda in the Federal Register and is requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including any assessments that EPA has started this year. [Federal Register Notice May 7, 2012]
Oct 2010EPA announced the 2011 IRIS Agenda in the Federal Register. [Federal Register Oct 18, 2010]
Oct 2009EPA announced the 2009/10 IRIS Agenda in the Federal Register with an announcement of the IRIS Update Project. [Federal Register Oct 21, 2009]
Dec 2007EPA announced the 2008 IRIS Agenda in the Federal Register. [Federal Register Dec 21, 2007 ]
Dec 2006EPA announced the 2007 IRIS Agenda in the Federal Register. [Federal Register Dec 22, 2006]
Feb 2006EPA announced the 2006 IRIS Agenda in the Federal Register. [Federal Register Feb 23, 2006]

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