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IRIS Toxicological Review of Acrylonitrile (2011 Interagency Science Consultation Draft)
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Contact
- Norman Birchfield
- by phone at: 703-347-0174
- by fax at: 703-347-8699
- by email at: birchfield.norman@epa.gov
- by fax at: 703-347-8699
Downloads/Related Links
- Toxicological Review of Acrylonitrile: in Support of Summary Information on the Integrated Risk Information System (IRIS) (Interagency Science Consultation Draft) (PDF) (767 pp, 4 MB, about PDF)
- Selected Sections and Highlights of the External Peer Review Draft of Acrylonitrile (June 2011) (PDF) (6 pp, 52 KB, about PDF)
- Charge to External Reviewers (Interagency Science Consultation Draft) (PDF) (4 pp, 36 KB, about PDF)
- Interagency Science Consultation Comments and EPA's Response to Major Comments (PDF) (14 pp, 66 KB, about PDF)
Related Link(s)
Background
The draft Toxicological Review of Acrylonitrile provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to acrylonitrile. Acrylonitrile is widely used in the production of acrylic fibers, plastics (acrylonitrile butadiene styrene and acrylonitrile-styrene resins), and nitrile rubbers, and as an intermediate in the production of other chemicals. Exposures most relevant to the public are inhalation of emitted acrylonitrile in the vicinity of industrial sources, and ingestion of acrylonitrile monomer migrated from plastic containers into food and drink.
History/Chronology
| Sep 1987 | The cancer assessment for acrylonitrile was posted to the IRIS database. |
| Nov 1991 | The inhalation RfC for acrylonitrile was posted to the IRIS database. |
| Mar 2010 | EPA hosted an interagency science consultation on the review of the draft Toxicological Review of Acrylonitrile. |
| May 2010 | Following a report from the National Toxicology Program, EPA placed the draft Acryolnitrile Toxicological Review on hold. (See June 15, 2010 press release) |
| Jun 2011 | EPA hosted a second interagency science consultation on the review of the selected sections and highlights to the external peer review draft of the Toxicological Review of Acrylonitrile. |
| Jun 2011 | EPA released the external review draft of the acrylonitrile assessment for public review and comment. |
Next Steps
Following external peer review the assessment will be revised taking into consideration external peer review and public comments, will undergo a final EPA internal review and a review by a science discussion with other federal agencies and White House offices, then will be posted to the IRIS Web site.
Citation
U.S. EPA. IRIS Toxicological Review of Acrylonitrile (2011 Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/013C, 2011.