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- Jamie B. Strong
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The U.S. EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of dibutyl phthalate that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable
information quality guidelines. It has not been
formally disseminated by EPA. It does not represent and should not be construed to represent any Agency
determination or policy.
EPA is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of dibutyl phthalate. These documents are provided for public viewing and comment. Public comments received on the Toxicological Review or IRIS Summary prior to July 14, 2006 were provided to the external peer reviewers for their consideration. Any comments received by July 21, 2006 were considered by EPA in subsequent drafts.
Dibutyl phthalate is used as a plasticizer for nitrocellulose, polyvinyl acetate, and polyvinyl chloride; a lubricant for aerosol valves; an antifoaming agent; a skin emollient; and a plasticizer in nail polish, fingernail elongators, and hair spray. Dibutyl phthalate is: 1) classified as a Hazardous Air Pollutant under the 1990 Clean Air Act amendments; 2) included on the Office of Prevention, Pesticides and Toxic Substances 1990 high production volume chemical list; 3) listed as a Toxic Release Inventory chemical; and 4) found at hazardous waste and Superfund sites. The assessment will present reference values for the noncancer effects of dibutyl phthalate (RfD and RfC), where supported by available data, and a cancer assessment. The Toxicological Review will be subject to an internal and external peer review.
This draft has been archived.
U.S. EPA. IRIS Toxicological Review of Dibutyl Phthalate (DBP) (External Review Draft) 2006. U.S. Environmental Protection Agency, Washington, DC, NCEA-S-1755, 2006.