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Archived Drafts & Comments

IRIS
List of IRIS Substances



EPA is dedicated to listening and being responsive to the public, independent experts and scientists in other federal agencies and White House offices while it develops IRIS assessments. To maximize the transparency of IRIS assessment development, the draft documents shared with these groups during the IRIS assessment development process are made available below.

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Substance Name Interagency Science
Consultation
External Review Interagency Science
Discussion
1,4-Dioxane (inhalation)
 IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)  IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)  IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)
1,4-Dioxane  IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)  IRIS Toxicological Review of 1,4-Dioxane (External Review Draft, 2009)  IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010
Acetone
 IRIS Toxicological Review and Summary Documents for Acetone (External Review Draft)
Acrolein  IRIS Toxicological Review and Summary Documents for Acrolein (External Review Draft)
Acrylamide  IRIS Toxicological Review of Acrylamide (External Review Draft)  IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)
Acrylonitrile  IRIS Toxicological Review of Acrylonitrile (2011 Interagency Science Consultation Draft)  IRIS Toxicological Review of Acrylonitrile (2011 External Review Draft)
Ammonia  IRIS Toxicological Review of Ammonia (Interagency Science Consultation Draft)  IRIS Toxicological Review of Ammonia (External Review Draft) (Jun 2012)
Arsenic, Inorganic (Cancer)  IRIS Toxicological Review of Inorganic Arsenic (Cancer) (Interagency Science Consultation Draft)  IRIS Toxicological Review of Inorganic Arsenic (Cancer) (2010 External Review Draft)
Benzene
 Extrapolation of the Benzene Inhalation Unit Risk Estimate to the Oral Route of Exposure (External Review Draft)
Benzo(a)pyrene  IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Consultation Draft)
Beryllium  IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft)
Biphenyl  IRIS Toxicological Review of Biphenyl (Interagency Science Consultation Draft)  IRIS Toxicological Review of Biphenyl (External Review Draft) (September 2011)  IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft)
Boron  IRIS Toxicological Review and Summary Documents for Boron and Compounds (Third External Review Draft 2002)
Bromobenzene  IRIS Toxicological Review of Bromobenzene (External Review Draft)
Cadmium
 IRIS Toxicological Review of Cadmium and Compounds (External Review Draft)
Carbon Tetrachloride  IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft)  IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft)
Cerium Oxide  IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft)  IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (Interagency Science Discussion Draft)
Chlordecone  IRIS Toxicological Review of Chlordecone (Kepone) (External Review Draft)  IRIS Toxicological Review of Chlordecone (Interagency Science Discussion Draft)
Chloroethane  IRIS Toxicological Review and Summary Documents for Chloroethane (External Review Draft)
Chloroprene  IRIS Toxicological Review of Chloroprene (2000 External Review Draft)  IRIS Toxicological Review of Chloroprene (Interagency Science Discussion Draft)
Cis & Trans Dichloroethylene  IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)  IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)  IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)
Cyanobacterial Toxins: Anatoxin-a  IRIS Toxicological Review of Cyanobacterial Toxins: Anatoxin-a (External Review Draft)
Cyanobacterial Toxins: Cylindrospermopsin  IRIS Toxicological Review of Cyanobacterial Toxins: Cylindrospermopsin (External Review Draft)
Cyanobacterial Toxins: Microcystins LR RR YR and LA  IRIS Toxicological Review of Cyanobacterial Toxins: Microcystins LR, RR, YR and LA (External Review Draft)
Decabromodiphenyl Ether
 IRIS Toxicological Review of Decabromodiphenyl Ether (External Review Draft)
Dibutyl Phthalate  IRIS Toxicological Review of Dibutyl Phthalate (DBP) (External Review Draft) 2006
Dichlorobenzenes  IRIS Toxicological Review of Dichlorobenzenes (2004 External Review Draft)
Dichloromethane  IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)  IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (External Review Draft)  IRIS Toxicological Review of Dichloromethane (Dcm) (Interagency Science Discussion Draft)
Dioxin  EPA's Response to "Health Risks from Dioxin and Related Compounds Evaluation of the EPA Reassessment" Published By the National Research Council of the National Academies (Interagency Science Consultation Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1) (Interagency Science Discussion Draft)
Ethyl Tertiary Butyl Ether
 IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (2009 External Review Draft)
Ethylene Glycol Mono-Butyl Ether  IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (External Review Draft)  IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (Interagency Science Discussion Draft)
Ethylene Oxide  Evaluation of the Carcinogenicity of Ethylene Oxide (External Review Draft 2006)  Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Interagency Science Discussion Draft)
Formaldehyde
 IRIS Toxicological Review of Formaldehyde (Interagency Science Consultation Draft)
Halogenated Platinum Salts
 IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)
Hexabromodiphenyl Ether  IRIS Toxicological Review of Hexabromodiphenyl Ether (External Review Draft)
Hexachlorocylopentadiene  IRIS Toxicological Review of Hexachlorocyclopentadiene [and IRIS Summary] (External Review Draft)
Hexachloroethane  IRIS Toxicological Review of Hexachloroethane (Interagency Science Consultation Draft)  IRIS Toxicological Review of Hexachloroethane (External Review Draft)  IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft)
Hexane  IRIS Toxicological Review and Summary Documents for N-Hexane (External Review Draft)
Hexanone  IRIS Toxicological Review of 2-Hexanone (External Review Draft)  IRIS Toxicological Review of 2-Hexanone (Interagency Science Discussion Draft)
Hexavalent Chromium  IRIS Toxicological Review of Hexavalent Chromium (Interagency Science Consultation Draft)  IRIS Toxicological Review of Hexavalent Chromium (2010 External Review Draft)
Hydrogen Cyanide  IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)  IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft)
Hydrogen Sulfide  IRIS Toxicological Review and Summary Documents for Hydrogen Sulfide (External Review Draft)
Libby Amphibole Asbestos
 IRIS Toxicological Review of Libby Amphibole Asbestos (Interagency Science Consultation Draft)
Methanol (non-cancer)
 IRIS Toxicological Review of Methanol (Interagency Science Consultation Draft)  IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)
Methanol (noncancer)  IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)
Methanol  IRIS Toxicological Review of Methanol (Interagency Science Consultation Draft)  IRIS Toxicological Review of Methanol (External Review Draft; December 2009)  IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)
Methyl Ethyl Ketone  IRIS Toxicological Review of Methyl Ethyl Ketone [and IRIS Summary] (External Review Draft)
Methylnaphthalene  IRIS Toxicological Review and Summary Documents for 2-Methylnaphthalene (External Review Draft)
Mirex  IRIS Toxicological Review of Mirex (2003 External Review Draft)
Naphthalene
 IRIS Toxicological Review of Naphthalene (2004 External Review Draft, Update)
Nitrobenzene  IRIS Toxicological Review of Nitrobenzene (External Review Draft)
Pentabromodiphenyl Ether
 IRIS Toxicological Review of Pentabromodiphenyl Ether (External Review Draft)
Pentachlorophenol  IRIS Toxicological Review of Pentachlorophenol (External Review Draft)  IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft)
Perchlorate  Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization Based on Emerging Information (External Review Draft) 1998
Phosgene  IRIS Toxicological Review of Phosgene (External Review Draft)
Propionaldehyde  IRIS Toxicological Review of Propionaldehyde (External Review Draft)
Quinoline
 IRIS Toxicological Review of Quinoline [and IRIS Summary] (External Review Draft)
Tetrabromodiphenyl Ether
 IRIS Toxicological Review of 2,2',4,4'-Tetrabromodiphenyl Ether (External Review Draft)
Tetrachlorodibenzo-p-dioxin  EPA's Response to "Health Risks from Dioxin and Related Compounds Evaluation of the EPA Reassessment" Published By the National Research Council of the National Academies (Interagency Science Consultation Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1) (Interagency Science Discussion Draft)
Tetrachloroethane  IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft)  IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft)
Tetrachloroethylene (PERC)  IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft)  IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft)
Tetrahydrofuran  IRIS Toxicological Review of Tetrahydrofuran (THF) (External Review Draft)  IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft)
Thallium  IRIS Toxicological Review of Thallium and Compounds (External Review Draft)
Toluene  IRIS Toxicological Review and Summary Documents for Toluene (Second External Review Draft)
Trichloroacetic Acid  IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Consultation Draft)  IRIS Toxicological Review of Trichloroacetic Acid (External Review Draft)  IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)
Trichloroethane  IRIS Toxicological Review and Summary Documents for 1,1,1-Trichloroethane (External Review Draft)
Trichloroethylene  IRIS Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft)  IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)  IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft)
Trichloropropane  IRIS Toxicological Review of 1,2,3-Trichloropropane (External Review Draft)  IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft)
Trimethylbenzene  IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft)  IRIS Toxicological Review of Trimethylbenzenes (External Review Draft) (Jun 2012)
Trimethylpentane  IRIS Toxicological Review and Summary Documents for 2,2,4-Trimethylpentane (External Review Draft)
Urea
 IRIS Toxicological Review of Urea (Interagency Science Consultation Draft)  IRIS Toxicological Review of Urea (External Review Draft)  IRIS Toxicological Review of Urea (Interagency Science Discussion Draft)
Vanadium Pentoxide
 IRIS Toxicological Review of Vanadium Pentoxide (Interagency Science Consultation Draft)
Vinyl Chloride  IRIS Toxicological Review and Summary Documents for Vinyl Chloride (External Review Draft)
Xylenes
 IRIS Toxicological Review and Summary Documents for Xylenes (External Review Draft)
Zinc
 IRIS Toxicological Review and Summary Documents for Zinc and Compounds (External Review Draft)


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