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Archived Drafts & Comments

IRIS
List of IRIS Substances



EPA is dedicated to listening and being responsive to the public, independent experts and scientists in other federal agencies and White House offices while it develops IRIS assessments. To maximize the transparency of IRIS assessment development, the draft documents shared with these groups during the IRIS assessment development process are made available below.

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Substance Name Preliminary Assessment
Material
Interagency
Science
Consultation
Public Comment
Drafts
External
Review
Revised External
Review
Interagency
Science
Discussion
Final
1,3-Butadiene
 Health Assessment Document for 1,3-Butadiene (External Review Draft)
1,4-Dioxane (inhalation)  IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)  IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)  IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)
1,4-Dioxane  IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)  IRIS Toxicological Review of 1,4-Dioxane (External Review Draft, 2009)  IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)
Acetone
 IRIS Toxicological Review of Acetone (External Review Draft)
Acrolein  IRIS Toxicological Review and Summary Documents for Acrolein (External Review Draft)
Acrylamide  IRIS Toxicological Review of Acrylamide (External Review Draft)  IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)
Acrylonitrile  IRIS Toxicological Review of Acrylonitrile (Interagency Science Consultation Draft)  IRIS Toxicological Review of Acrylonitrile (External Review Draft)  Health Assessment Document for Acrylonitrile (Final Report, 1983)
Ammonia  IRIS Toxicological Review of Ammonia (Interagency Science Consultation Draft)  IRIS Toxicological Review of Ammonia (External Review Draft)  IRIS Toxicological Review of Ammonia (Revised External Review Draft)  IRIS Toxicological Review of Ammonia Noncancer Inhalation (Interagency Science Discussion Draft)
Arsenic, Inorganic (Cancer)  IRIS Toxicological Review of Inorganic Arsenic (Cancer) (Interagency Science Consultation Draft, 2009)
Arsenic, Inorganic  IRIS Toxicological Review of Inorganic Arsenic (Cancer) (Interagency Science Consultation Draft, 2009)  IRIS Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft, 2010)
Benzene
 Extrapolation of the Benzene Inhalation Unit Risk Estimate to the Oral Route of Exposure (External Review Draft)
Benzo(a)pyrene  IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Consultation Draft)  IRIS Toxicological Review of Benzo[a]pyrene (Public Comment Draft)
Benzo[a]pyrene
Beryllium  IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft)
Biphenyl  IRIS Toxicological Review of Biphenyl (Interagency Science Consultation Draft)  IRIS Toxicological Review of Biphenyl (External Review Draft) (September 2011)  IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft)
Boron  IRIS Toxicological Review and Summary Documents for Boron and Compounds (Third External Review Draft 2002)
Bromobenzene  IRIS Toxicological Review of Bromobenzene (External Review Draft)
Cadmium
 IRIS Toxicological Review of Cadmium and Compounds (External Review Draft)
Carbon Tetrachloride  Health Assessment Document for Carbon Tetrachloride (External Review Draft,1982)  IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft)  Health Assessment Document for Carbon Tetrachloride (Final Report, 1984)
Cerium Oxide  IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft)  IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (Interagency Science Discussion Draft)
Chlordecone  IRIS Toxicological Review of Chlordecone (Kepone) (External Review Draft)  IRIS Toxicological Review of Chlordecone (Interagency Science Discussion Draft)
Chloroethane  IRIS Toxicological Review and Summary Documents for Chloroethane (External Review Draft)
Chloroprene  IRIS Toxicological Review of Chloroprene (2000 External Review Draft)  IRIS Toxicological Review of Chloroprene (Interagency Science Discussion Draft)
Chromium (VI)  Health Effects Assessment for Hexavalent Chromium (1984 Final)
Chromium(VI)  IRIS Toxicological Review of Hexavalent Chromium (Interagency Science Consultation Draft, 2022)  IRIS Toxicological Review of Hexavalent Chromium (2010 External Review Draft)  Health Assessment Document for Chromium (1983 Final)
Cis & Trans Dichloroethylene  IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)  IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)  IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)
Decabromodiphenyl Ether
 IRIS Toxicological Review of Decabromodiphenyl Ether (External Review Draft)
Dibutyl Phthalate  IRIS Toxicological Review of Dibutyl Phthalate (DBP) (External Review Draft) 2006
Dichlorobenzene  IRIS Toxicological Review of Dichlorobenzenes (2004 External Review Draft)
Dichloromethane  IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)  IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (External Review Draft)  IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Discussion Draft)
Diesel engine exhaust  Health Assessment Document for Diesel Emissions (External Review Draft)  Health Assessment Document for Diesel Exhaust (Revised External Review Draft)
Dioxin  EPA's Response to Health Risks from Dioxin and Related Compounds Evaluation of the EPA Reassessment Published By the National Research Council of the National Academies (Interagency Science Consultation Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1) (Interagency Science Discussion Draft)
Ethyl Tertiary Butyl Ether
 IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (Interagency Science Consultation Draft, 2016)  IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (Public Comment Draft, 2016)  IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (External Review Draft, 2009)  IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (Interagency Science Discussion Draft, 2020)
Ethylene Glycol Mono-Butyl Ether  IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (External Review Draft)  IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (Interagency Science Discussion Draft)
Ethylene Oxide  Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised July 2013 External Review Draft) (Public Comment Draft)  Health Assessment Document for Ethylene Oxide (External Review Draft)  Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (2011 Interagency Science Discussion Draft)
Formaldehyde
 IRIS Toxicological Review of Formaldehyde (Interagency Science Consultation Draft, 2010)  IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft, 2010)
Halogenated Platinum Salts
 IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)
Hexabromodiphenyl Ether  IRIS Toxicological Review of Hexabromodiphenyl Ether (External Review Draft)
Hexachlorocylopentadiene  IRIS Toxicological Review of Hexachlorocyclopentadiene [and IRIS Summary] (External Review Draft)
Hexachloroethane  IRIS Toxicological Review of Hexachloroethane (Interagency Science Consultation Draft)  IRIS Toxicological Review of Hexachloroethane (External Review Draft)  IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft)
Hexane  IRIS Toxicological Review and Summary Documents for N-Hexane (External Review Draft)
Hexanone  IRIS Toxicological Review of 2-Hexanone (External Review Draft)  IRIS Toxicological Review of 2-Hexanone (Interagency Science Discussion Draft)
Hexavalent Chromium  IRIS Toxicological Review of Hexavalent Chromium (2010 Interagency Science Consultation Draft)  Health Effects Assessment for Hexavalent Chromium (1984 Final)
Hydrogen Sulfide  IRIS Toxicological Review and Summary Documents for Hydrogen Sulfide (External Review Draft)
IRIS, Carbon Tetrachloride
 IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft)
IRIS, chloroform  IRIS Toxicological Review of Chloroform (Final Report, 2001)
IRIS, chromium VI  IRIS Toxicological Review of Chromium VI (1998 Final)
IRIS, hydrogen cyanide and cyanide salts  IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)  IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft)
IRIS  IRIS Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft)  IRIS Toxicological Review of Benzo[a]pyrene (Public Comment Draft)  Extrapolation of the Benzene Inhalation Unit Risk Estimate to the Oral Route of Exposure (External Review Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)  IRIS Toxicological Review of 2-Hexanone (Interagency Science Discussion Draft)  Health Assessment Document for Carbon Tetrachloride (Final Report, 1984)
Libby Amphibole Asbestos
 IRIS Toxicological Review of Libby Amphibole Asbestos (Interagency Science Consultation Draft)  IRIS Toxicological Review of Libby Amphibole Asbestos (External Review Draft)  IRIS Toxicological Review of Libby Amphibole Asbestos (Interagency Science Discussion Draft)
Methanol (non-cancer)
 IRIS Toxicological Review of Methanol (Interagency Science Consultation Draft)  IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)
Methanol (noncancer)  IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)
Methanol  IRIS Toxicological Review of Methanol (Interagency Science Consultation Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)  IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)
Methyl Ethyl Ketone  IRIS Toxicological Review of Methyl Ethyl Ketone [and IRIS Summary] (External Review Draft)
Methylmercury  Reference Dose for Methylmercury (External Review Draft, 2000)
Methylnaphthalene  IRIS Toxicological Review and Summary Documents for 2-Methylnaphthalene (2003, External Review Draft)
Mirex  IRIS Toxicological Review of Mirex (2003 External Review Draft)
Naphthalene
 IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update)  IRIS Toxicological Review of Naphthalene (1998, Final)
Nitrobenzene  IRIS Toxicological Review of Nitrobenzene (External Review Draft)
PFAS
 IRIS Toxicological Review of Perfluorohexanoic Acid (Pfhxa) and Related Salts (Interagency Science Consultation Draft, 2021)
Pathalates  Phthalates and Cumulative Risk Assessment (NAS Final Report)
Pentabromodiphenyl Ether  IRIS Toxicological Review of Pentabromodiphenyl Ether (External Review Draft)
Pentachlorophenol  IRIS Toxicological Review of Pentachlorophenol (External Review Draft)  IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft)
Perchlorate  Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization Based on Emerging Information (External Review Draft) 1998
Phosgene  IRIS Toxicological Review of Phosgene (External Review Draft)
Polycyclic Aromatic Hydrocarbon  IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Consultation Draft)  Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft, Suspended)
Propionaldehyde  IRIS Toxicological Review of Propionaldehyde (External Review Draft)
Quinoline
 IRIS Toxicological Review of Quinoline [and IRIS Summary] (External Review Draft)
RDX
 IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Interagency Science Consultation Draft)  IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Public Comment Draft)  IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (External Review Draft)  IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Interagency Science Discussion Draft)
Tert-Butanol
 IRIS Toxicological Review of tert-Butyl Alcohol (Tba) (Public Comment Draft, 2016)  IRIS Toxicological Review of tert-Butyl Alcohol (Tba) (External Review Draft, 2017)  IRIS Toxicological Review of tert-Butyl Alcohol (Tba) (Interagency Science Discussion Draft, 2020)
Tert-Butyl Alcohol  IRIS Toxicological Review of tert-Butyl Alcohol (TBA) (Interagency Science Consultation Draft, 2014)
Tetrabromodiphenyl Ether  IRIS Toxicological Review of 2,2',4,4'-Tetrabromodiphenyl Ether (External Review Draft)
Tetrachlorodibenzo-p-dioxin  EPA's Response to Health Risks from Dioxin and Related Compounds Evaluation of the EPA Reassessment Published By the National Research Council of the National Academies (Interagency Science Consultation Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft)  EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1) (Interagency Science Discussion Draft)
Tetrachloroethane  IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft)  IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft)
Tetrachloroethylene (PERC)  IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft)  IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft)
Tetrahydrofuran  IRIS Toxicological Review of Tetrahydrofuran (THF) (External Review Draft)  IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft)
Thallium  IRIS Toxicological Review of Thallium and Compounds (External Review Draft)
Toluene  IRIS Toxicological Review and Summary Documents for Toluene (Second External Review Draft)
Trichloroacetic Acid  IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Consultation Draft)  IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)  IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)
Trichloroethane  IRIS Toxicological Review and Summary Documents for 1,1,1-Trichloroethane (External Review Draft)
Trichloroethylene  IRIS Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft)  IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)  IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft)
Trichloropropane  IRIS Toxicological Review of 1,2,3-Trichloropropane (External Review Draft)  IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft)
Trimethylbenzene  IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft)  IRIS Toxicological Review of Trimethylbenzenes (Revised External Review Draft)  IRIS Toxicological Review of Trimethylbenzenes (Revised External Review Draft)  IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Discussion Draft)
Trimethylpentane  IRIS Toxicological Review and Summary Documents for 2,2,4-Trimethylpentane (External Review Draft)
Urea
 IRIS Toxicological Review of Urea (Interagency Science Consultation Draft)  IRIS Toxicological Review of Urea (External Review Draft)  IRIS Toxicological Review of Urea (Interagency Science Discussion Draft)
Vanadium Pentoxide
 IRIS Toxicological Review of Vanadium Pentoxide (Interagency Science Consultation Draft)
Vinyl Chloride  IRIS Toxicological Review and Summary Documents for Vinyl Chloride (External Review Draft)
Xylenes
 IRIS Toxicological Review and Summary Documents for Xylenes (External Review Draft)
Zinc
 IRIS Toxicological Review and Summary Documents for Zinc and Compounds (External Review Draft)
n-butanol
 IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft)  IRIS Toxicological Review of n-Butanol (External Review Draft)
naphthalene  IRIS Toxicological Review and Summary Documents for 2-Methylnaphthalene (2003, External Review Draft)  Final Report from the External Peer Review of the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene (2004)
vanadium pentoxide
 IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft, 2012)


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