IRIS

Methyl isobutyl ketone (MIBK)

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 162 K) Last Updated: 04/25/2003
Information reviewed but value not estimated.

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Developmental, Musculoskeletal	3	Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats.	NOAEL (HEC): 1026 mg/m³	300	Low/Medium

Weight of Evidence for Cancer (PDF) (23 pp, 162 K) Last Updated: 04/25/2003

WOE Characterization	Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential	Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)

Basis:

Under the draft revised cancer guidelines (U.S. EPA, 1999), the data for MIBK are inadequate for an assessment of human carcinogenic potential. No data were located regarding the existence of an association between cancer and MIBK exposure in humans, but studies of the in vivo and in vitro genotoxicity of MIBK overwhelmingly provided negative responses.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.