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Propionaldehyde Quickview (CASRN 123-38-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Propionaldehyde

File First On-Line: 09/30/2008; Last Significant Revision: 09/30/2008

Category (section)
Last Revised
Oral RfD Assessment Discussion 09/30/2008
Inhalation RfC Assessment Yes 09/30/2008
Carcinogenicity Assessment Yes 09/30/2008
  • Propanal
  • Propionic Aldehyde
  • Methylacetaldehyde
  • Propyl Aldehyde
  • Propaldehyde
  • Propylic Aldehyde
  • Propionaldehyde
  • 123-38-6
Propionaldehyde Source Documents
Revision History
Date Section Description
09/30/2008 I., II. RfD, RfC, and cancer assessment first on line.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Atrophy of olfactory epithelium BMCL10 (HEC): 8 mg/m3 1000 8x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • In accordance with the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" for propionaldehyde.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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