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Hydrogen Cyanide and Cyanide Salts Quickview (CASRN Various)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Hydrogen Cyanide and Cyanide Salts

File First On-Line: 01/31/1987; Last Significant Revision: 09/28/2010

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/28/2010
Inhalation RfC Assessment On-line 09/28/2010
Carcinogenicity Assessment Discussion 09/28/2010
Synonyms
  • Calcyanide
  • oxalonitrile
  • Cyclone B
  • Prussic acid
  • Cyanogran
  • Cymag
  • dicyanogen
  • ethanedinitrile
  • hydrocyanic acid
  • Cyanobrik
  • white cyanide
  • more...
Hydrogen Cyanide and Cyanide Salts Source Documents
Revision History
Date Section Description
09/28/2010 I., II., VI. RfD and RfC assessment updated cancer assessment added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
 UF RfD
Decreased cauda epididymis weight in male F344/N rats BMDL (1SD): 1.9 mg/kg-day 3000 0.0006 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
 UF RfC
Thyroid enlargement and altered iodide uptake LOAEL (ADJ): 2.5 mg/m3 3000 0.0008 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the U.S. EPA (2005a) Guidelines for Carcinogen Risk Assessment, there is "inadequate information to assess the carcinogenic potential" of cyanide.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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