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Barium and Compounds Quickview (CASRN 7440-39-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Barium and Compounds

File First On-Line: 01/31/1987; Last Significant Revision: 07/11/2005

Category (section)
Last Revised
Oral RfD Assessment Yes 07/11/2005
Inhalation RfC Assessment Yes 03/30/1998
Carcinogenicity Assessment Yes 03/30/1998
  • 7440-39-3
  • Barium
  • UN 1399
  • UN 1400
  • UN 1854
  • Barium and Compounds
Barium and Compounds Source Documents
Revision History
Date Section Description
01/21/1999 I.A. Minor revisions to RfD Assessment, revised critical effect
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Nephropathy BMDL05 : 63 mg/kg-day 300 2 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
    • Carcinogenic potential cannot be determined (Inhalation route)
    • Not likely to be carcinogenic to humans (Oral route)
  • Weight-of-Evidence Narrative:
    • Under EPA's 1986 Guidelines for Carcinogen Risk Assessment, barium would be classified as Group D, not classifiable as to human carcinogenicity. Under the Proposed Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 1996), barium is considered not likely to be carcinogenic to humans following oral exposure and its carcinogenic potential cannot be determined following inhalation exposure.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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