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2,3,7,8-Tetrachlorodibenzo-p-dioxin Quickview (CASRN 1746-01-6)

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Status of Data for 2,3,7,8-Tetrachlorodibenzo-p-dioxin

File First On-Line: 02/17/2012; Last Significant Revision: 02/17/2012

Category (section)
Last Revised
Oral RfD Assessment Yes 02/17/2012
Inhalation RfC Assessment No 02/17/2012
Carcinogenicity Assessment Discussion 02/17/2012
  • 1746-01-6
  • 2,3,7,8-tetrachlorodibenzo-p-dioxin
  • TCDD
  • Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-
  • Dibenzo-p-dioxin, 2,3,7,8-tetrachloro-
  • 2,3,7,8-TCDD
  • Tetrachlorodibenzodioxin
  • 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin
  • 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin
  • Tetradioxin
  • Dioxin
Revision History
Date Section Description
02/17/2012 I.A. RfD added
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates LOAEL (ADJ): 2 x10-8 mg/kg-day 30 7 x10-10 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Assessment underway at the time of the last significant revision.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Assessment underway at the time of the last significant revision.

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