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Tetrahydrofuran Quickview (CASRN 109-99-9)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Tetrahydrofuran

File First On-Line: 02/21/2012; Last Significant Revision: 02/21/2012

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/21/2012
Inhalation RfC Assessment On-line 02/21/2012
Carcinogenicity Assessment On-line 02/21/2012
Synonyms
  • 109-99-9
  • THF
  • diethyleneoxide
  • tetramethyleneoxide
  • 1,4-epoxy butane
  • furanidine
  • oxacyclopentane
  • Tetrahydrofuran
Tetrahydrofuran Source Documents
Revision History
Date Section Description
02/21/2012 I., II, and VI. RfD and RfC added, cancer assessment added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Decreased pup body weight gain BMDL1SD : 928 mg/kg-day 1000 9 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Increased liver weight and centrilobular cytomegaly, CNS effects (narcosis) BMCL10 : 246 mg/m3 100 2 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Suggestive evidence of carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for THF provides "suggestive evidence of carcinogenic potential."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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