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2-Hexanone Quickview (CASRN 591-78-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 2-Hexanone

File First On-Line: 09/25/2009; Last Significant Revision: 09/25/2009

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/25/2009
Inhalation RfC Assessment On-line 09/25/2009
Carcinogenicity Assessment On-line 09/25/2009
Synonyms
  • 2-Hexanone
  • 591-78-6
  • 2-Oxohexane
  • Butyl methyl ketone
  • Hexanone-2
  • Ketone, butyl methyl
  • Methyl butyl ketone
  • Methyl n-butyl ketone
  • Propylacetone
  • n-Butyl methyl ketone
2-Hexanone Source Documents
Revision History
Date Section Description
09/25/2009 I., II. RfD, RfC, and cancer assessment first on-line
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Axonal swelling of the peripheral nerve BMDL10 : 5 mg/kg-day 1000 5 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Motor conduction velocity of the sciatic-tibial nerve BMCL05 (HEC): 90 mg/m3 3000 3x10-2 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 2-hexanone is "inadequate to assess human carcinogenic potential."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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