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Chlordecone (Kepone) Quickview (CASRN 143-50-0)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Chlordecone (Kepone)

File First On-Line: 09/22/2009; Last Significant Revision: 09/22/2009

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/22/2009
Inhalation RfC Assessment Discussion 09/22/2009
Carcinogenicity Assessment On-line 09/22/2009
Synonyms
  • Chlordecone (Kepone)
  • 143-50-0
  • decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]-pentalen-2-one
  • GC-1189
Chlordecone (Kepone) Source Documents
Revision History
Date Section Description
09/22/2009 I., II. RfD, RfC, and cancer assessment first on line
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Renal lesions (glomerulosclerosis) in female Wistar rats BMDL10 : 0.08 mg/kg-day 300 0.0003 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the U.S. EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), chlordecone is "likely to be carcinogenic to humans" based on data from an oral cancer bioassay in rats and mice demonstrating an increase in the incidence of hepatocellular carcinomas in both sexes of both species (NCI, 1976a, b).
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
10 per mg/kg-day Multistage-Weibull model (implemented in TOX_RISK) with linear extrapolation from the POD (BMDL10).
Drinking Water Unit Risks
3x10-4 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 0.33 µg/L
E-5 (1 in 100,000) 0.033 µg/L
E-6 (1 in 1,000,000) 0.0033 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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