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2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) Quickview (CASRN 5436-43-1)

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Status of Data for 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)

File First On-Line: 06/30/2008; Last Significant Revision: 06/30/2008

Category (section)
Last Revised
Oral RfD Assessment Yes 06/30/2008
Inhalation RfC Assessment Discussion 06/30/2008
Carcinogenicity Assessment Yes 06/30/2008
  • Benzene, 1,1'-oxybis(2,4-dibromo)-
  • PBDE 47
  • BDE-47
  • 5436-43-1
  • 2,2',4,4'-Tetrabromodiphenyl ether
Revision History
Date Section Description
06/30/2008 I., II. RfD, RfC, and cancer assessment first on line.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Neurobehavioral effects BMDL (1SD): 0.35 mg/kg 3000 1 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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