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Perchlorate (ClO4) and Perchlorate Salts Quickview (CASRN 7790-98-9)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Perchlorate (ClO4) and Perchlorate Salts

File First On-Line: 02/18/2005; Last Significant Revision: 02/18/2005

Category (section)
Last Revised
Oral RfD Assessment Yes 02/18/2005
Inhalation RfC Assessment Discussion 02/18/2005
Carcinogenicity Assessment Yes 02/18/2005
  • Perchlorate (ClO4) and Perchlorate Salts
  • Ammonium perchlorate
  • 7790-98-9
  • 7791-03-9
  • Lithium perchlorate
  • 7778-74-7
  • Potassium perchlorate
  • 7601-89-0
  • Sodium perchlorate
Revision History
Date Section Description
02/18/2005 All IRIS assessment for Perchlorate and Perchlorate Salts added to the database.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Radioactive iodide uptake inhibition (RAIU) in the thyroid NOEL : 7 x10-3 mg/kg-day 10 7 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Not likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under U.S. EPAs 1999 Draft Revised Guidelines for Carcinogen Risk Assessment, perchlorate is not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and species differences in thyroid function.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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