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Cyclohexane Quickview (CASRN 110-82-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Cyclohexane

File First On-Line: 09/11/2003; Last Significant Revision: 09/11/2003

Category (section)
Last Revised
Oral RfD Assessment Discussion 09/11/2003
Inhalation RfC Assessment Yes 09/11/2003
Carcinogenicity Assessment Discussion 09/11/2003
  • Benzenehexahydride
  • Benzene, hexahydro-cicloesano (Italian)
  • Cyclohexaan (Dutch)
  • Cyclohexan (German)
  • Cykloheksan (Polish)
  • Hexahydrobenzene
  • Hexamethylene
  • Hexanaphthene
Cyclohexane Source Documents
Revision History
Date Section Description
all IRIS summary first posted.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Reduced pup weights in the F1 and F2 generations BMCL1sd (HEC): 1822 mg/m3 300 6 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Data are inadequate for an assessment of human carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Cyclohexane is characterized as "Data are inadequate for an assessment of human carcinogenic potential" (U.S. EPA, 1999).
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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