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Quinoline Quickview (CASRN 91-22-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Quinoline

File First On-Line: 09/27/2001; Last Significant Revision: 09/27/2001

Category (section)
Status
Last Revised
Oral RfD Assessment Message 09/27/2001
Inhalation RfC Assessment Message 09/27/2001
Carcinogenicity Assessment On-line 09/27/2001
Synonyms
  • 91-22-5
  • 1-Azanaphthalene
  • 1-Benzazine
  • Benzopyridine
  • Leucoline
  • Benzo[b]pyridine
  • 1-Benzine
  • Chinoleine
  • Chinoline
  • Leucol
  • Leukol
  • B-500
Quinoline Source Documents
Revision History
Date Section Description
I.,II.,VI Assessment first on-line
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
    • Known/likely human carcinogen
  • Weight-of-Evidence Narrative:
    • Quinoline is considered likely to be carcinogenic in humans in accordance with proposed EPA carcinogen risk assessment guidelines (U.S. EPA, 1996) on the basis of observations of exposure-related increased incidence of an unusual malignant tumor in multiple strains of rats and mice, multiple experiments using oral, i.p. and s.c. dosing at an early age. This determination is supported by studies that demonstrate that quinoline is genotoxic.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
3 per mg/kg-day Time-to-tumor, multistage-Weibull
Drinking Water Unit Risks
9x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 1 µg/L
E-5 (1 in 100,000) 1x10-1 µg/L
E-6 (1 in 1,000,000) 1x10-2 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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