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Methyl methacrylate Quickview (CASRN 80-62-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Methyl methacrylate

File First On-Line: 03/02/1998; Last Significant Revision: 03/02/1998

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 03/02/1998
Inhalation RfC Assessment On-line 03/02/1998
Carcinogenicity Assessment On-line 03/02/1998
Synonyms
  • Methacrylic acid, methyl ester
  • Methacrylate monomer
  • Methyl a-methylacrylate
  • Methyl 2-methyl-2-propenoate
  • Methyl methacrylate
Methyl methacrylate Source Documents
Revision History
Date Section Description
03/02/1998 I.A., I.B., II., VI. New RfD, RfC, cancer assessments
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
None NOAEL : 1.36 x102 mg/kg-day 100 1.4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Degeneration/ atrophy of olfactory epithelium (male rats) BMC10 (HEC): 7.2 mg/m3 10 7x10-1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • E (Evidence of non-carcinogenicity for humans)
    • Not likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under EPA's 1986 Guidelines for Carcinogen Risk Assessment, MMA would be classified as evidence of non-carcinogenicity for humans or a Group E chemical. Under the Proposed Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 1996), MMA is considered not likely to be carcinogenic to humans by any route of exposure because it has been evaluated in four well-conducted chronic inhalation studies in three appropriate animal species without demonstrating carcinogenic effects.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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