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Chlorodifluoromethane Quickview (CASRN 75-45-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Chlorodifluoromethane

File First On-Line: 11/01/1993; Last Significant Revision: 11/01/1993

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Yes 11/01/1993
Carcinogenicity Assessment No
  • 75-45-6
  • Methane, chlorodifluoro-
  • Fluorocarbon 22
  • Hydrochlorofluorocarbon 22
  • Algeon 22
  • Algofrene Type 6
  • CCRIS 858
  • Chlorofluorocarbon 22
  • Difluorochloromethane
  • Difluoromonochloromethane
  • Electro-CF 22
  • more...
Chlorodifluoromethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Increased kidney, adrenal and pituitary weights (other effect: Reduced maternal weight gain. ) NOAEL (HEC): 5.260 x103 mg/m3 100 5x101 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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