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Dichloroacetic acid Quickview (CASRN 79-43-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Dichloroacetic acid

File First On-Line: 02/01/1996; Last Significant Revision: 09/11/2003

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/11/2003
Inhalation RfC Assessment Discussion 09/11/2003
Carcinogenicity Assessment On-line 09/11/2003
Synonyms
  • Acido dicloroacetico [Spanish]
  • 79-43-6
  • Acetic acid, dichloro-
  • AI3-18370
  • Dichlorethanoic acid
  • Kyselina dichloroctova [Czech]
  • Dichloroacetic acid
  • Acide dichloracetique [French]
Dichloroacetic acid Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Lesions observed in the testes, cerebrum, cerebellum, and liver. LOAEL : 12.5 mg/kg-day 3000 4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • EPA believes that DCA is likely to be a carcinogen in humans.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5 x10-2 per mg/kg-day Multistage model with Benchmark Dose Modeling
Drinking Water Unit Risks
1.4x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 7x101 µg/L
E-5 (1 in 100,000) 7 µg/L
E-6 (1 in 1,000,000) 7x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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