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Dichloroacetic acid Quickview (CASRN 79-43-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Dichloroacetic acid

File First On-Line: 02/01/1996; Last Significant Revision: 09/11/2003

Category (section)
Last Revised
Oral RfD Assessment Yes 09/11/2003
Inhalation RfC Assessment Discussion 09/11/2003
Carcinogenicity Assessment Yes 09/11/2003
  • 79-43-6
  • Acetic acid, dichloro-
  • Acide dichloracetique [French]
  • AI3-18370
  • Dichlorethanoic acid
  • Kyselina dichloroctova [Czech]
  • Acido dicloroacetico [Spanish]
  • Dichloroacetic acid
Dichloroacetic acid Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Lesions observed in the testes, cerebrum, cerebellum, and liver. LOAEL : 12.5 mg/kg-day 3000 4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • EPA believes that DCA is likely to be a carcinogen in humans.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5 x10-2 per mg/kg-day Multistage model with Benchmark Dose Modeling
Drinking Water Unit Risks
1.4x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 7x101 µg/L
E-5 (1 in 100,000) 7 µg/L
E-6 (1 in 1,000,000) 7x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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