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1,6-Hexamethylene diisocyanate Quickview (CASRN 822-06-0)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 1,6-Hexamethylene diisocyanate

File First On-Line: 09/01/1994; Last Significant Revision: 09/01/1994

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment On-line 09/01/1994
Carcinogenicity Assessment No data
Synonyms
  • 822-06-0
  • Hexane, 1,6-diisocyanato-
  • Hexamethylene diisocyanate
  • 1,6-Hexamethylene diisocyanate
  • AI3-28285
  • Diisocyanate d'hexamethylene [French]
  • HDI
  • Hexamethylendiisokyanat [Czech]
  • Hexamethylene diisocyanate
  • Hexamethylenediisocyanate
  • Hexametilendilsocianato [Spanish]
  • more...
1,6-Hexamethylene diisocyanate Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Degeneration of olfactory epithelium NOAEL (HEC): 1 x10-3 mg/m3 100 1x10-5 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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