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1,4-Dichlorobenzene Quickview (CASRN 106-46-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 1,4-Dichlorobenzene

File First On-Line: 01/01/1994; Last Significant Revision: 01/01/1994

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Yes 01/01/1994
Carcinogenicity Assessment No
  • 106-46-7
  • 1,4-Dichloorbenzeen [Dutch]
  • 1,4-dichlorobenzene
  • 1,4-Diclorobenzene [Italian]
  • Benzene, 1,4-dichloro-
  • Benzene, p-dichloro-
  • Caswell No. 632
  • Di-chloricide
  • Dichlorobenzene, para
  • EPA Pesticide Chemical Code 061501
  • Evola
  • more...
1,4-Dichlorobenzene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Increased liver weights in P1 males NOAEL (HEC): 7.5 x101 mg/m3 100 8x10-1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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