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Methyl tert-butyl ether (MTBE) Quickview (CASRN 1634-04-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Methyl tert-butyl ether (MTBE)

File First On-Line: 12/01/1991; Last Significant Revision: 09/01/1993

Category (section)
Status
Last Revised
Oral RfD Assessment No data 03/01/1993
Inhalation RfC Assessment On-line 09/01/1993
Carcinogenicity Assessment No data
Under Re-Assessment
Synonyms
  • 1634-04-4
  • Propane, 2-methoxy-2-methyl-
  • Methyl tert-butyl ether
  • t-Butyl methyl ether
  • Ether methyl tert-butylique [french]
  • Ether, tert-butyl methyl
  • HSDB 5847
  • Methyl 1,1-dimethylethyl ether
  • Methyl-tert-butyl ether
  • Methyl-tert-butylether
  • Metil-terc-butileter [spanish]
  • more...
Methyl tert-butyl ether (MTBE) Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females) NOAEL (HEC): 2.59 x102 mg/m3 100 3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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