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1,4-Dithiane Quickview (CASRN 505-29-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 1,4-Dithiane

File First On-Line: 03/01/1991; Last Significant Revision: 03/01/1993

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 03/01/1993
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 02/01/1993
Synonyms
  • 505-29-3
  • 1,4-Dithiane
  • NSC 24178
  • 1,4-Dithiacyclohexane
  • 1,4-Dithiin, tetrahydro-
  • p-Dithiane
  • Dithiane
1,4-Dithiane Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Nasal olfactory lesions LOAEL : 1.05 x102 mg/kg-day 10000 1 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • Based on no data in humans and animals.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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