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Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol) Quickview (CASRN 111-76-2)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)

File First On-Line: 12/30/1999; Last Significant Revision: 03/31/2010

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 03/31/2010
Inhalation RfC Assessment On-line 03/31/2010
Carcinogenicity Assessment On-line 03/31/2010
Synonyms
  • Ethylene glycol monobutyl ether (EGBE)
  • CASRN -- 111-76-2
  • 2-Butoxyethanol
  • Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
  • Bucs
  • Butoxyethanol
  • N-Butoxyethanol
  • 2-Butoxy-1-Ethanol
  • Butyl Cellosolve
  • O-Butyl Ethylene Glycol
  • Butyl Glycol
  • more...
Revision History
Date Section Description
03/31/2010 I., II., VI. RfD, RfC, and cancer assessment sections updated.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Hemosiderin deposition in the liver BMDL (HED): 1.4 mg/kg-day 10 0.1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Hemosiderin deposition in the liver BMCL (HEC): 16 mg/m3 10 1.6 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Not likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), EGBE is deemed "not likely to be carcinogenic to humans" at environmental concentrations at or below the RfD and RfC, based on laboratory animal evidence, mode-of-action information, and limited human study information.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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