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Chlorine dioxide Quickview (CASRN 10049-04-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Chlorine dioxide

File First On-Line: 11/01/1990; Last Significant Revision: 10/11/2000

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 10/12/2000
Inhalation RfC Assessment On-line 10/12/2000
Carcinogenicity Assessment On-line 10/12/2000
Synonyms
  • 10049-04-4
  • Chlorine oxide
  • Alcide
  • Anthium dioxcide
  • Caswell No. 179A
  • Chlorine dioxide
  • Chlorine peroxide
  • Chlorine (IV) oxide
  • Chloroperoxyl
  • Chloryl radical
  • Dioxide de cloro [Spanish]
  • more...
Chlorine dioxide Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Neurodevelopmental effects NOAEL : 3 mg/kg-day 100 3 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Vascular congestion and peribronchial edema (other effect: Hemorrhagic alveoli and congested capillaries in the lungs. ) LOAEL (HEC): 6.4 x10-1 mg/m3 3000 2x10-4 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
    • Carcinogenic potential cannot be determined
  • Weight-of-Evidence Narrative:
    • Under the current guidelines (U.S. EPA, 1986), chlorine dioxide is classified as Group D; not classifiable as to human carcinogenicity because of inadequate data in humans and animals. Under the draft Carcinogen Assessment Guidelines (U.S. EPA, 1996), the human carcinogenicity of chlorine dioxide cannot be determined because no satisfactory human or animal studies assessing the chronic carcinogenic potential of chlorine dioxide have been located.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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