Jump to main content.


Phosgene Quickview (CASRN 75-44-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Phosgene

File First On-Line: 10/01/1990; Last Significant Revision: 01/31/2006

Category (section)
Status
Last Revised
Oral RfD Assessment Discussion 01/31/2006
Inhalation RfC Assessment On-line 01/31/2006
Carcinogenicity Assessment On-line 01/31/2006
Synonyms
  • 75-44-5
  • Carbon Dichloride Oxide
  • Carbone (oxychlorure de) [French]
  • Carbonic dichloride
  • Carbonio (ossicloruro di) [Italian]
  • Carbon oxychloride
  • Carbonylchlorid [German]
  • Carbonyl chloride
  • Carbonyl dichloride
  • CG
  • Chloroformyl chloride
  • more...
Phosgene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

Top of page


Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Collagen staining indicative of fibrosis BMDL10 (HEC): 3 x10-2 mg/m3 100 3x10-4 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

Top of page

Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), there is inadequate information to assess carcinogenic potential of phosgene. A single epidemiology study was not considered adequate for evaluating carcinogenic potential in humans, and no animal cancer bioassays of phosgene have been conducted.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

Top of page


Recent Additions | Advanced Search | IRIS Home | Environmental Assessment | Research


Local Navigation


Jump to main content.