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Phosgene Quickview (CASRN 75-44-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Phosgene

File First On-Line: 10/01/1990; Last Significant Revision: 01/31/2006

Category (section)
Last Revised
Oral RfD Assessment Discussion 01/31/2006
Inhalation RfC Assessment Yes 01/31/2006
Carcinogenicity Assessment Yes 01/31/2006
  • 75-44-5
  • Carbon Dichloride Oxide
  • Carbone (oxychlorure de) [French]
  • Carbonic dichloride
  • Carbonio (ossicloruro di) [Italian]
  • Carbon oxychloride
  • Carbonylchlorid [German]
  • Carbonyl chloride
  • Carbonyl dichloride
  • CG
  • Chloroformyl chloride
  • more...
Phosgene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Collagen staining indicative of fibrosis BMDL10 (HEC): 3 x10-2 mg/m3 100 3x10-4 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), there is inadequate information to assess carcinogenic potential of phosgene. A single epidemiology study was not considered adequate for evaluating carcinogenic potential in humans, and no animal cancer bioassays of phosgene have been conducted.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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