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n-Hexane Quickview (CASRN 110-54-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for n-Hexane

File First On-Line: 07/01/1990; Last Significant Revision: 12/23/2005

Category (section)
Last Revised
Oral RfD Assessment Discussion 12/23/2005
Inhalation RfC Assessment Yes 12/23/2005
Carcinogenicity Assessment Yes 12/23/2005
  • 110-54-3
  • n-Hexane
  • Hexyl hydride
  • NCI-C60571
  • Skellysolve B
n-Hexane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Peripheral neuropathy (decreased MCV at 12 weeks) BMCL (HEC): 215 mg/m3 300 7x10-1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the emGuidelines for Carcinogen Risk Assessment/em (U.S. EPA, 2005b), there is eminadequate information to assess the carcinogenic potential of n-hexane./em
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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