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Zinc and Compounds Quickview (CASRN 7440-66-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Zinc and Compounds

File First On-Line: 02/01/1991; Last Significant Revision: 08/03/2005

Category (section)
Last Revised
Oral RfD Assessment Yes 08/03/2005
Inhalation RfC Assessment Discussion 08/03/2005
Carcinogenicity Assessment Yes 08/03/2005
  • 7440-66-6
  • Zinc
  • Asarco l 15
  • Blue powder
  • Cinc [Spanish]
  • Emanay zinc dust
  • Granular zinc
  • HSDB 1344
  • Jasad
  • Lead refinery vacuum zinc
  • Merrillite
  • more...
Zinc and Compounds Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers LOAEL : 0.91 mg/kg-day 3 3 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
    • Data are inadequate for an assessment of human carcinogenic potential
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess carcinogenic potential of zinc, because studies of humans occupationally-exposed to zinc are inadequate or inconclusive, adequate animal bioassays of the possible carcinogenicity of zinc are not available, and results of genotoxic tests of zinc have been equivocal.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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