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Di(2-ethylhexyl)adipate Quickview (CASRN 103-23-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Di(2-ethylhexyl)adipate

File First On-Line: 10/01/1989; Last Significant Revision: 07/01/1992

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 07/01/1992
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 12/01/1994
Under Re-Assessment
Synonyms
  • 103-23-1
  • Adipol 2EH
  • BEHA
  • bis(2-Ethylhexyl) adipate
  • bis-(2-Ethylhexyl)ester kyseliny adipove [Czech]
  • Bisoflex DOA
  • DEHA
  • Di-2-ethylhexyl adipate
  • DOA
  • Effemoll DOA
  • Effomoll DOA
  • more...
Di(2-ethylhexyl)adipate Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Changes in body weight and liver weight increased liver weight of male and female parents; reduced ossification and slightly dilated ureters in fetuses; reduced offspring weight gain, total litter weight, and litter size NOAEL : 1.70 x102 mg/kg-day 300 6 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on an absence of human data and increased incidence of liver tumors in female mice. Except for a positive dominant lethal assay, there was no evidence of genotoxicity; this compound does, however, exhibit structural relationships to other nongenotoxic compounds classified as probable and possible human carcinogens.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.2 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
3.4x10-8 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 3x103 µg/L
E-5 (1 in 100,000) 3x102 µg/L
E-6 (1 in 1,000,000) 3x101 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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