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cis-1,2-Dichloroethylene Quickview (CASRN 156-59-2)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for cis-1,2-Dichloroethylene

File First On-Line: 12/01/1990; Last Significant Revision: 09/30/2010

Category (section)
Last Revised
Oral RfD Assessment Yes 09/30/2010
Inhalation RfC Assessment Discussion 09/30/2010
Carcinogenicity Assessment Yes 09/30/2010
  • 156-59-2
  • Ethene, 1,2-dichloro-, (Z)-
  • (Z)-1,2-Dichloroethene
  • (Z)-1,2-Dichloroethylene
  • cis-1,2-Dichlorethylene
  • cis-1,2-Dichloroethene
  • cis-1,2-Dichloroethylene
  • Ethene, 1,2-dichloro-, (Z)-
  • HSDB 5656
  • NSC 6149
  • 1,2-cis-Dichloroethylene
  • more...
cis-1,2-Dichloroethylene Source Documents
Revision History
Date Section Description
09/30/2010 I., II., VI. RfD assessment added; RfC and cancer assessment sections revised.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Increased relative kidney weight in male rats BMDL10 : 5.1 mg/kg-day 3000 0.002 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" of cis-1,2-DCE.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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