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Boron and Compounds Quickview (CASRN 7440-42-8)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Boron and Compounds

File First On-Line: 10/01/1989; Last Significant Revision: 08/05/2004

Category (section)
Last Revised
Oral RfD Assessment Yes 08/05/2004
Inhalation RfC Assessment Discussion 08/05/2004
Carcinogenicity Assessment Yes 08/05/2004
  • 7440-42-8
  • Boron
  • Boron (Boron and Borates only)
  • Boron and Compounds
Boron and Compounds Source Documents
Revision History
Date Section Description
I.A., I.B., II Revised RfD, added RfC discussion and added carcinogenicity assessment.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased fetal weight (developmental) BMDL05 : 10.3 mg/kg-day 66 2 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Data are inadequate for an assessment of human carcinogenic potential (Oral route)
  • Weight-of-Evidence Narrative:
    • Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), data are inadequate for an assessment of human carcinogenic potential for boron.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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