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Nitroguanidine Quickview (CASRN 556-88-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Nitroguanidine

File First On-Line: 09/01/1989; Last Significant Revision: 09/01/1990

Category (section)
Last Revised
Oral RfD Assessment Yes 09/01/1989
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 09/01/1990
  • 556-88-7
  • Nitroguanidine
  • alpha-Nitroguanidine
  • 1-Nitroguanidine
  • 2-Nitroguanidine
  • Nitroguanidine, dry (dot)
  • Picrite (The Explosive)
  • UN 0282 (dot)
  • Guanidine, nitro-
Nitroguanidine Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Reduced weight gain in female rats, maternal/ fetal toxicity in rats, and equivocal evidence of developmental toxicity in rabbits NOAEL : 3.16 x102 mg/kg-day 3000 1 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • Pertinent data regarding carcinogenicity have not been located in the available literature.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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