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Chlorobenzene Quickview (CASRN 108-90-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Chlorobenzene

File First On-Line: 08/01/1989; Last Significant Revision: 11/01/1990

Category (section)
Last Revised
Oral RfD Assessment Yes 08/01/1989
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 11/01/1990
  • 108-90-7
  • Benzene chloride
  • Benzene, chloro-
  • Chloorbenzeen [Dutch]
  • Chlorbenzol
  • Chlorobenzen [Polish]
  • Chlorobenzenu [Czech]
  • Chlorobenzol
  • Clorobenzene [Italian]
  • Monochlorbenzene
  • Monochlorbenzol [German]
  • more...
Chlorobenzene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Histopathologic changes in liver NOAEL : 1.9 x101 mg/kg-day 1000 2 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • No human data, inadequate animal data and predominantly negative genetic toxicity data in bacterial, yeast, and mouse lymphoma cells.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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