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2,4-/2,6-Dinitrotoluene mixture Quickview (CASRN NA)

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Status of Data for 2,4-/2,6-Dinitrotoluene mixture

File First On-Line: 09/01/1990; Last Significant Revision: 09/01/1990

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 09/01/1990
Synonyms
  • 2,4-Dinitrotoluol
  • RCRA Waste Number u105
  • RCRA Waste Number u106
  • Benzene, 2-methyl-1,3-dinitro-
  • 121-14-2
  • 2,4-Dinitrotoluene
  • 2,4-DNT
  • HSDB 1144
  • HSDB 2931
  • NSC 7194
  • Toluene, 2,4-dinitro-
  • more...
2,4-/2,6-Dinitrotoluene mixture Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on multiple benign and malignant tumor types at multiple sites in both sexes of rats (2 strains) and malignant renal tumors in male mice. The classification is supported by evidence of mutagenicity.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
6.8 x10-1 per mg/kg-day Linearized multistage procedure
Drinking Water Unit Risks
1.9x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 5 µg/L
E-5 (1 in 100,000) 5x10-1 µg/L
E-6 (1 in 1,000,000) 5x10-2 µg/L
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas
    • Test Species: Rat/Sprague-Dawley, female
    • Route: Oral, Diet
    • Reference: Ellis et al., 1979

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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