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Benzyl chloride Quickview (CASRN 100-44-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Benzyl chloride

File First On-Line: 08/01/1989; Last Significant Revision: 01/01/1992

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Message 01/01/1992
Carcinogenicity Assessment Yes 08/01/1989
  • 100-44-7
  • Benzene, (chloromethyl)-
  • Benzile (cloruro di) [Italian]
  • Benzyl chloride
  • Benzyle (chlorure de) [French]
  • Benzylchlorid [German]
  • Chloromethylbenzene
  • Chlorophenylmethane
  • alpha-Chlorotoluene
  • omega-Chlorotoluene
  • Alpha-Chlortoluol [German]
  • more...
Benzyl chloride Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on inadequate human data and sufficient evidence of carcinogenicity in animals; namely significantly increased incidences of benign and malignant tumors at multiple sites in both sexes of mice and a significant increase in thyroid tumors in female rats. There was evidence of mutagenicity in a variety of test systems.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.7 x10-1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
4.9x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 2x101 µg/L
E-5 (1 in 100,000) 2 µg/L
E-6 (1 in 1,000,000) 2x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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