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Benzotrichloride Quickview (CASRN 98-07-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Benzotrichloride

File First On-Line: 07/01/1990; Last Significant Revision: 07/01/1990

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 12/01/1990
Synonyms
  • 98-07-7
  • AI3-02583
  • Benzene, (trichloromethyl)-
  • Benzenyl chloride
  • Benzenyl trichloride
  • Benzoic trichloride
  • Benzotrichloride
  • Benzotricloruro [Spanish]
  • Benzylidyne chloride
  • Benzyl trichloride
  • Chlorure de benzenyle [French]
  • more...
Benzotrichloride Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on inadequate human data and sufficient evidence of carcinogenicity in animals; namely, significantly increased incidences of benign and malignant tumors at multiple sites in one strain of female mice treated orally, dermally, and by inhalation. There is also evidence of mutagenicity in a variety of test systems.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.3 x101 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
3.6x10-4 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 3.0x10-1 µg/L
E-5 (1 in 100,000) 3.0x10-2 µg/L
E-6 (1 in 1,000,000) 3.0x10-3 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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