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4,4'-Methylene bis(N,N'-dimethyl)aniline Quickview (CASRN 101-61-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 4,4'-Methylene bis(N,N'-dimethyl)aniline

File First On-Line: 08/01/1989; Last Significant Revision: 08/01/1989

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 08/01/1990
Synonyms
  • 101-61-1
  • Aniline, 4,4'-methylenebis(n,n-dimethyl-
  • Baze michlerova (Czech)
  • Benzenamine, 4-4'-methylenebis(n,n-dimethyl)-
  • p,p'-bis(Dimethylamino)diphenylmethane
  • 4,4'-bis(Dimethylamino)diphenylmethane
  • bis(p-Dimethylaminophenyl)methane
  • bis(4-(Dimethylamino)phenyl)methane
  • bis(p-(n,n-Dimethylamino)phenyl)methane
  • bis(4-(n,n-Dimethylamino)phenyl)methane
  • p,p'-bis(n,n-Dimethylaminophenyl)methane
  • more...
4,4'-Methylene bis(N,N'-dimethyl)aniline Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Sufficient evidence from animal experiments: thyroid tumors in male and female rats, and liver carcinoma/adenoma in the female mice with a significant positive trend in male mice. There is evidence of mutagenic activity. There are no human data.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
4.6 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.3x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 8x101 µg/L
E-5 (1 in 100,000) 8 µg/L
E-6 (1 in 1,000,000) 8x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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