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Prochloraz Quickview (CASRN 67747-09-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Prochloraz

File First On-Line: 01/01/1989; Last Significant Revision: 10/01/1989

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 01/01/1989
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 01/01/1997
Synonyms
  • 67747-09-5
  • Prochloraz
  • BTS 40542
Prochloraz Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Increase in SAP and liver weights, liver histopathology NOEL : 9.0 x10-1 mg/kg-day 100 9 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Statistically significantly increased incidence and dose-related trend in liver adenomas and carcinomas (combined) in both sexes of one strain of mouse.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.5 x10-1 per mg/kg-day Male mice: time-to-tumor linearized multistage procedure in dose, Weibull in time. Female mice: linearized multistage procedure
Drinking Water Unit Risks
4.3x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2x101 µg/L
E-5 (1 in 100,000) 2 µg/L
E-6 (1 in 1,000,000) 2x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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