Jump to main content.

Prochloraz Quickview (CASRN 67747-09-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Prochloraz

File First On-Line: 01/01/1989; Last Significant Revision: 10/01/1989

Category (section)
Last Revised
Oral RfD Assessment Yes 01/01/1989
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 10/01/1989
  • 67747-09-5
  • Prochloraz
  • BTS 40542
Prochloraz Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Increase in SAP and liver weights, liver histopathology NOEL : 9.0 x10-1 mg/kg-day 100 9 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Top of page

Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

Top of page

Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Statistically significantly increased incidence and dose-related trend in liver adenomas and carcinomas (combined) in both sexes of one strain of mouse.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.5 x10-1 per mg/kg-day Male mice: time-to-tumor linearized multistage procedure in dose, Weibull in time. Female mice: linearized multistage procedure
Drinking Water Unit Risks
4.3x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 2x101 µg/L
E-5 (1 in 100,000) 2 µg/L
E-6 (1 in 1,000,000) 2x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

Top of page

Recent Additions | Advanced Search | IRIS Home | Environmental Assessment | Research

Local Navigation

Jump to main content.