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Bis(chloromethyl)ether (BCME) Quickview (CASRN 542-88-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Bis(chloromethyl)ether (BCME)

File First On-Line: 09/26/1988; Last Significant Revision: 07/01/1991

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Message 07/01/1991
Carcinogenicity Assessment Yes 09/26/1988
  • 542-88-1
  • Bis(chloromethyl)ether
  • Chloro(chloromethoxy)methane
  • Dichlordimethylaether
  • 1,1'-Dichlorodimethyl ether
  • sym-Dichloro-dimethyl ether
  • Dimethyl-1,1'-dichloroether
  • Ether, bis(chloromethyl)
  • Methane, oxybis(chloro-
  • Oxybis(chloromethane)
  • RCRA Waste Number p016
  • more...
Bis(chloromethyl)ether (BCME) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • A (Human carcinogen)
  • Weight-of-Evidence Narrative:
    • Statistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2.2 x102 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
6.2x10-3 per µg/L
Risk Level
E-4 (1 in 10,000) 1.6x10-2 µg/L
E-5 (1 in 100,000) 1.6x10-3 µg/L
E-6 (1 in 1,000,000) 1.6x10-4 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
6.2 x10-2 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 1.6x10-3 µg/m3
E-5 (1 in 100,000) 1.6x10-4 µg/m3
E-6 (1 in 1,000,000) 1.6x10-5 µg/m3

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