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Hexachlorobenzene Quickview (CASRN 118-74-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Hexachlorobenzene

File First On-Line: 09/26/1988; Last Significant Revision: 03/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 04/01/1991
Inhalation RfC Assessment Message 03/01/1991
Carcinogenicity Assessment On-line 11/01/1996
Synonyms
  • 118-74-1
  • Granox
  • Pentachlorophenyl chloride
  • Perchlorobenzene
  • Hexachlorobenzene
Hexachlorobenzene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Liver effects NOAEL : 8 x10-2 mg/kg-day 100 8 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Hexachlorobenzene, when administered orally, has been shown to induce tumors in the liver, thyroid and kidney in three rodent species.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.6 per mg/kg-day Linearized multistage, extra risk
Drinking Water Unit Risks
4.6x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2 µg/L
E-5 (1 in 100,000) 2x10-1 µg/L
E-6 (1 in 1,000,000) 2x10-2 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
4.6 x10-4 per µg/m3 Linearized multistage, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 2x10-1 µg/m3
E-5 (1 in 100,000) 2x10-2 µg/m3
E-6 (1 in 1,000,000) 2x10-3 µg/m3

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