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Mercury, elemental Quickview (CASRN 7439-97-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Mercury, elemental

File First On-Line: 09/07/1988; Last Significant Revision: 06/01/1995

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Yes 06/01/1995
Carcinogenicity Assessment Yes 05/01/1995
  • Hydragyrum
  • Mercury, elemental
  • Mercury, metallic
  • Mercury (organo) alkyl compounds
  • Caswell No. 546
  • Colloidal mercury
  • Kwik [Dutch]
  • Liquid silver
  • Mercure [French]
  • Mercurio [Italian]
  • Mercurio [Spanish]
  • more...
Mercury, elemental Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Hand tremor; increases in memory disturbances; slight subjective and objective evidence of autonomic dysfunction LOAEL (ADJ): 9 x10-3 mg/m3 30 3x10-4 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • Based on inadequate human and animal data. Epidemiologic studies failed to show a correlation between exposure to elemental mercury vapor and carcinogenicity; the findings in these studies were confounded by possible or known concurrent exposures to other chemicals, including human carcinogens, as well as lifestyle factors (e.g., smoking). Findings from genotoxicity tests are severely limited and provide equivocal evidence that mercury adversely affects the number or structure of chromosomes in human somatic cells.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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