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Furmecyclox Quickview (CASRN 60568-05-0)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Furmecyclox

File First On-Line: 09/07/1988; Last Significant Revision: 09/07/1988

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 10/01/1993
Synonyms
  • 60568-05-0
  • BAS 389
  • Campogran
  • 3-Furancarboxamide, n-cyclohexyl-n-methoxy-2,5-dimethyl-
  • Furmecyclox
  • Furmetamide
  • GUS 215
  • n-Cyclohexyl-n-methoxy-2,5-dimethyl-3-furancarboxamide
  • Xyligen b
Furmecyclox Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Dose-related increased incidence of neoplastic nodules, carcinomas and combined neoplasic nodules/carcinomas in the liver of female rats and increased incidence of liver nodules and carcinomas and urothelial tumors of the bladder in male rats.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
3.0 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
8.6x10-7 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 1x102 µg/L
E-5 (1 in 100,000) 1x101 µg/L
E-6 (1 in 1,000,000) 1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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