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1,2-Dibromoethane Quickview (CASRN 106-93-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 1,2-Dibromoethane

File First On-Line: 01/01/1991; Last Significant Revision: 07/29/2004

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 07/29/2004
Inhalation RfC Assessment On-line 07/29/2004
Carcinogenicity Assessment On-line 07/29/2004
Synonyms
  • 106-93-4
  • Dibromoethane
  • 1,2-Dibromoethane
  • Dibromoethane, 1,2-
  • alpha,beta-Dibromoethane
  • Ethylene bromide
  • Ethylene dibromide
  • Glycol dibromide
  • s-Dibromoethane
1,2-Dibromoethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Testicular atrophy, liver peliosis, and adrenal cortical degeneration LOAEL : 27 mg/kg-day 3000 9 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Nasal inflammation BMCL10 (HEC): 2.8 mg/m3 300 9x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), 2-dibromoethane is considered "likely to be carcinogenic to humans" based on strong evidence of carcinogenicity in animals and inconclusive evidence of carcinogenicity in an exposed human population.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2 per mg/kg-day
(95% upper bound)
Multistage model with Poly-3 adjusted incidence data; linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range.
Drinking Water Unit Risks
6x10-5 per µg/L
(95% upper bound)
Risk Level
Concentration
E-4 (1 in 10,000) 2 µg/L(95% upper bound)
E-5 (1 in 100,000) 2x10-1 µg/L(95% upper bound)
E-6 (1 in 1,000,000) 2x10-2 µg/L(95% upper bound)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
3 x10-4 per µg/m3 3
(central tendency estimate)
6 x10-4 per µg/m3
(95% upper bound)
Multistage-Weibull model; linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range.

3 This is one endpoint in a range of inhalation unit risks. Additional Comments (Carcinogenicity, Inhalation Exposure).

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 2x10-1 µg/m3(95% upper bound)
E-5 (1 in 100,000) 2x10-2 µg/m3(95% upper bound)
E-6 (1 in 1,000,000) 2x10-3 µg/m3(95% upper bound)
  • Dose-Response Data (Carcinogenicity, Inhalation Exposure)
    • Tumor Type: Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas
    • Test Species: Rat/ Fischer 344, male
    • Route: Inhalation
    • Reference: NTP, 1982

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