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Acephate Quickview (CASRN 30560-19-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Acephate

File First On-Line: 09/07/1988; Last Significant Revision: 05/01/1989

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/01/1990
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 10/01/1993
Synonyms
  • 75 sp
  • Acephate
  • Chevron re 12,420
  • ENT 27822
  • n-(Methoxy(methylthio)phosphinoyl)acetamide
  • Orthene
  • Orthene-755
  • Ortho 12420
  • Ortran
  • Ortril
  • o,s-Dimethylacetylphosphoroamidothioate
  • more...
Acephate Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Inhibition of brain ChE LEL : 1.2 x10-1 mg/kg-day 30 4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
8.7 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.5x10-7 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 4x102 µg/L
E-5 (1 in 100,000) 4x101 µg/L
E-6 (1 in 1,000,000) 4 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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