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Acephate Quickview (CASRN 30560-19-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Acephate

File First On-Line: 09/07/1988; Last Significant Revision: 05/01/1989

Category (section)
Last Revised
Oral RfD Assessment Yes 05/01/1989
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 09/07/1988
  • 30560-19-1
  • 75 sp
  • Acephate
  • Chevron re 12,420
  • ENT 27822
  • n-(Methoxy(methylthio)phosphinoyl)acetamide
  • Orthene
  • Orthene-755
  • Ortho 12420
  • Ortran
  • Ortril
  • more...
Acephate Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Inhibition of brain ChE LEL : 1.2 x10-1 mg/kg-day 30 4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
8.7 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.5x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 4x102 µg/L
E-5 (1 in 100,000) 4x101 µg/L
E-6 (1 in 1,000,000) 4 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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