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Aniline Quickview (CASRN 62-53-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Aniline

File First On-Line: 09/07/1988; Last Significant Revision: 11/01/1990

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Yes 11/01/1990
Carcinogenicity Assessment Yes 09/07/1988
  • 62-53-3
  • Aminobenzene
  • Aminophen
  • Aniline
  • Aniline-oil
  • Kyanol
  • Phenylamine
Aniline Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementarry Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Lack of toxicity (other effect: Mild spleen toxicity. ) NOAEL (HEC): 3.4 mg/m3 3000 1x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Induction of tumors of the spleen and the body cavity in two strains of rat, and some supporting genetic toxicological evidence.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5.7 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.6x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 6x102 µg/L
E-5 (1 in 100,000) 6x101 µg/L
E-6 (1 in 1,000,000) 6 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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