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Fomesafen Quickview (CASRN 72178-02-0)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Fomesafen

File First On-Line: 08/22/1988; Last Significant Revision: 08/22/1988

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 10/01/1993
Synonyms
  • 72178-02-0
  • Fomesafen
  • 5-(2-chloro-4-(Trifluoromethyl)phenoxy)-n-(methylsulfonyl)-2-nitrobenzamide
  • Flex
  • Fomesafene
  • PP021
  • Reflex
  • Benzamide, 5-(2-chloro-4-(trifluoromethyl)phenoxy)-n-(methylsulfonyl)-2-nitro-
Fomesafen Source Documents
Revision History
Date Section Description
04/01/1997 III., IV. V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Fomesafen produced liver adenomas and carcinomas in both sexes of Charles River CD-1 mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.9 x10-1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
5.4x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2x101 µg/L
E-5 (1 in 100,000) 2 µg/L
E-6 (1 in 1,000,000) 2x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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